The argument is that response time over the Internet is never as fast as over a local area network and that such systems cannot tolerate any level of unscheduled downtime inherent in using a cloud application.
Nevertheless, cloud systems are invading even this category of software. Although still in the minority, there are some vendors providing such low-latency applications as a cloud service.
One example is Plex Systems. And, interestingly, it is not a new example.
Read the rest of this post on the Avasant website: Deploying Low-Latency Applications in the Cloud.